43. Keng-Mean Lin, Wei Hu, Ty Dale Troutman, Michelle Jennings, Travis Brewer, Xiaoxia Li, Sambit Nanda, Philip Cohen, James A. Thomas, and Chandrashekhar Pasare, IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. 201 Ace myhomework myhomework writers acemywork

Even though microbial recognition by Toll including receptors (TLRs) is known to induce the synthesis of the major caspase-1 substrate pro-IL-1?, the function of TLRs is considered limited in up-regulation of the inflammasome components. During a virulent microbe