Human Dopamine D3 Receptors Mediate Mitogen-Activated Protein Kinase Activation Via a Phosphatidylinositol 3-Kinase and an Atypi Ace myhomework myhomework writers acemywork

It is thus proposed that D3 receptors also play a role in promoting MAPK-mediated cellular growth. However, compared to D2, D3 receptors less effectively bind with pertussis-sensitive Gi/Go proteins, suggesting that the pathways of D2 and D3 in promoting mitogenesis is not entirely the same, and D3-mediated growth may not even involve MAPK.